Synuclein.org

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Synuclein - Wikipedia

Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors. The name is a blend of the words "synapse" and "nucleus", as it was first found in the synapses in the electromotor nucleus of the electric ray.

En.wikipedia.org

DA: 16 PA: 15 MOZ Rank: 31

Synuclein - an overview | ScienceDirect Topics

William Dauer, in Parkinson's Disease, 2008. Synuclein biology. Synuclein-based cell and mouse models have been most commonly studied because of the clear relationship of …

Sciencedirect.com

DA: 21 PA: 30 MOZ Rank: 52

α-Synuclein in Parkinson's Disease - PMC - PubMed …

α-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD pathogenesis in a number of …

Ncbi.nlm.nih.gov

DA: 20 PA: 25 MOZ Rank: 47

Alpha-synuclein - Wikipedia

Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter …

En.wikipedia.org

DA: 16 PA: 21 MOZ Rank: 40

Pathological structural conversion of α-synuclein at the …

Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed …

Nature.com

DA: 14 PA: 28 MOZ Rank: 46

Structures of α-synuclein filaments from human brains …

Here we report that the cryo-EM structures of α-synuclein filaments from the brains of individuals with PD, PDD and DLB are made of a single protofilament (Lewy fold) that is …

Nature.com

DA: 14 PA: 28 MOZ Rank: 47

Synucleinopathies - an overview | ScienceDirect Topics

Synucleinopathies, also known as α -synucleinopathies, are a group of neurodegenerative disorders in which the primary pathology is the intracytoplasmic accumulation of α -synuclein …

Sciencedirect.com

DA: 21 PA: 48 MOZ Rank: 75

LRRK2 Variants Keep α-Synuclein from Forming Tetramers

Treating the cells with LRRK2 kinase inhibitors restored the tetramers and lessened the pathological phosphorylation. So did an inhibitor of stearoyl-CoA desaturase, an enzyme …

Alzforum.org

DA: 16 PA: 50 MOZ Rank: 90

The synucleins - PubMed

The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors is a marker for tumor progression. Normal …

Pubmed.ncbi.nlm.nih.gov

DA: 23 PA: 10 MOZ Rank: 41

Synucleinopathy - Wikipedia

Neurology. Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in …

En.wikipedia.org

DA: 16 PA: 21 MOZ Rank: 46

Alpha-Synuclein - an overview | ScienceDirect Topics

α-Synuclein is the major component of intraneuronal Lewy bodies, which are characteristic of PD and dementia with Lewy bodies [189]. α-Synuclein pathology is sometimes found together …

Sciencedirect.com

DA: 21 PA: 50 MOZ Rank: 98

Alpha-synuclein: Pathology, mitochondrial dysfunction and ...

Abstract. Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

Pubmed.ncbi.nlm.nih.gov

DA: 23 PA: 10 MOZ Rank: 44

Membrane interactions of intrinsically disordered proteins: The …

Alpha-synuclein contains a 35-residue (position 61-95) aggregation-prone patch initially described as the NAC (Non-Aβ Component of Alzheimer’s disease amyloid), that is thought to …

Ncbi.nlm.nih.gov

DA: 20 PA: 25 MOZ Rank: 57

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