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We found Websites Listing below when search with prognosticenrichment.com on Search Engine
Prognostic and predictive enrichment in sepsis - PubMed
Prognostic and predictive enrichment in sepsis Sepsis is a heterogeneous disease state that is both common and consequential in critically ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has hindered advances in the field beyond the current therapeutic standards, which consist of supportive care and antib …
Pubmed.ncbi.nlm.nih.govDA: 23 PA: 10 MOZ Rank: 33
Prognostic and predictive enrichment in sepsis - Nature
Prognostic enrichment refers to the selection of patients with a higher likelihood of having a disease-related outcome of interest, such as mortality 5, 10, 11.
Nature.comDA: 14 PA: 27 MOZ Rank: 42
R: Prognostic Enrichment with Real Data
Value. A list with components estimates: A data frame with the following summary measures for each biomarker threshold that is used to screen trial participants: ‘selected.biomarker.quantiles’: quantiles of observed biomarker values used for screening. ‘biomarker.screening.thresholds’: the values of the biomarker corresponding to the quantiles, ‘event.rate’: post-screening event ...
Search.r-project.orgDA: 20 PA: 50 MOZ Rank: 72
The potential of polygenic scores to improve cost and …
The first, termed ‘prognostic enrichment,’ aims to increase statistical power—and thus decrease sample size and cost—by increasing the proportion of patients likely to demonstrate disease onset or...
Nature.comDA: 14 PA: 28 MOZ Rank: 45
CDE发布《药物临床试验富集策略与设计指导原则(征求意见稿)》意 …
预后 型富集 ( Prognostic Enrichment ): 是指选择性地纳入更可能发生终点事件(如死亡或疾病恶化)的受试者,从而降低为达到统计学显著疗效所需样本量的一种研究策略或设计。 附录 2 :中英文对照表. 中文. 英文. 靶向治疗. Target Therapy. 病理生理学. Pathophysiology. 蛋白质组学. Proteomics. 单臂试验 ...
Aisoutu.comDA: 15 PA: 7 MOZ Rank: 26
R: Prognostic Enrichment with Simulated Data
Value. A list with components estimates: A data frame with the following summary measures for each biomarker threshold that is used to screen trial participants: ‘selected.biomarker.quantiles’: quantiles of observed biomarker values used for screening. ‘biomarker.screening.thresholds’: the values of the biomarker corresponding to the quantiles, ‘event.rate’: post-screening event ...
Search.r-project.orgDA: 20 PA: 50 MOZ Rank: 77
Biomarker Qualification Submissions | FDA
Prognostic enrichment biomarker to identify NASH patients more likely to experience clinical endpoints such as progression to cirrhosis, hepatic decompensation events during the timeframe of a ...
Fda.govDA: 11 PA: 50 MOZ Rank: 91
Prognostic enrichment design in clinical trials for autosomal …
Strategies for prognostic enrichment, such as image classification, should be used in the design of RCTs for ADPKD to increase their power and reduce their cost. autosomal dominant polycystic kidney disease, eGFR, HALT-PKD study, image classification, total kidney volume Topic: polycystic kidney, autosomal dominant kidney patient prognosis
Academic.oup.comDA: 16 PA: 31 MOZ Rank: 54
A Prognostic Enrichment Strategy for Selection of Patients With …
Combined thresholds for patient's age, PaO2/FIO2, plateau pressure, and extrapulmonary organ failure provides prognostic enrichment accuracy for stratifying and selecting acute respiratory distress syndrome patients for randomized controlled trials. Trial registration: ClinicalTrials.gov NCT00435110NCT00736892NCT02288949NCT02836444.
Pubmed.ncbi.nlm.nih.govDA: 23 PA: 10 MOZ Rank: 41
Prognostic Enrichment Design in Clinical Trials for Autosomal …
Discussion Prognostic enrichment strategies such as the entry criteria used for TEMPO 3:4 or preferably the proposed image classification should be used in RCTs for ADPKD to increase power and to reduce cost.", keywords = "autosomal dominant polycystic kidney disease, clinical trials, disease progression, image classification of ADPKD, kidney volume", author = "Irazabal, …
Mayoclinic.pure.elsevier.comDA: 28 PA: 50 MOZ Rank: 41
Prognostic Enrichment Design In Clinical Trials for ADPKD
PDF | On Oct 1, 2016, Theodore Steinman published Prognostic Enrichment Design In Clinical Trials for ADPKD | Find, read and cite all the research you need on ResearchGate
Researchgate.netDA: 20 PA: 50 MOZ Rank: 40
BioPETsurv: Biomarker Prognostic Enrichment Tool for Time-to …
Prognostic Enrichment is a strategy of enriching a clinical trial for testing an intervention intended to prevent or delay an unwanted clinical event. A prognostically enriched trial enrolls only patients who are more likely to experience the unwanted clinical event than the broader patient population (R. Temple (2010) <doi:10.1038/clpt.2010 ...
Rdrr.ioDA: 7 PA: 17 MOZ Rank: 35
The impact of sample size mis-estimations on the interpretation of ...
Reporting of sample size estimations was inconsistent in ARDS RCTs, and misspecification of CER and ATE was common. Prognostic enrichment strategies in ARDS RCTs based on all-cause mortality are unlikely to be successful. Bayesian methods can be used to prioritise interventions for future effectiveness RCTs. AbbreviationList:
Journal.chestnet.orgDA: 20 PA: 39 MOZ Rank: 71
enrichment_analysis : Prognostic Enrichment with Real Data
In BioPET: Biomarker Prognostic Enrichment Tool. Description Usage Arguments Value See Also Examples. Description. Evaluating biomarkers for prognostic enrichment of clinical trials using real data Usage
Rdrr.ioDA: 7 PA: 41 MOZ Rank: 61
Metabolic signatures of ARDS and ARDS heterogeneity
Biological subphenotypes of acute respiratory distress syndrome show prognostic enrichment in mechanically ventilated patients without acute respiratory distress syndrome. Am J Respir Crit Care Med 203: 1503–1511, 2021 . doi: 10.1164/rccm.202006-2522OC .
Journals.physiology.orgDA: 23 PA: 35 MOZ Rank: 72
NIOSHTIC-2 Publications Search - 20061419 - BioPETsurv: …
Biomarkers can be used to enrich a clinical trial for patients at higher risk for an outcome, a strategy termed "prognostic enrichment." Methodology is needed to evaluate biomarkers for prognostic enrichment of trials with time-to-event endpoints such as survival. Key considerations when considering prognostic enrichment include: clinical trial sample size; the number of …
Cdc.govDA: 11 PA: 31 MOZ Rank: 57
Similar companies to BenchSci | VentureRadar
We are developing a novel digital biomarker platform to help clinical trials succeed by identifying optimal patients that will have the right outcome. The company’s turn-key solutions are used for prognostic enrichment and for precise therapeutic response prediction, thereby lowering clinical trial costs and risk. We currently have products ...
Ventureradar.comDA: 20 PA: 50 MOZ Rank: 90
Neutrophil gelatinase-associated lipocalin is elevated in children …
Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low-and-middle-income countries where diagnosis of acute kidney injury remains a challenge. To study this, we prospectively enrolled 250 children with sickle cell anemia aged …
Kidney-international.orgDA: 28 PA: 39 MOZ Rank: 84
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