Lacripep

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Lacripep
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Related websites

Lacripep for the Treatment of Primary Sjögren-Associated

Jul 1, 2023 Purpose: The purpose of this study was to assess the safety, tolerability, dosing, and efficacy of the active 19 amino acid fragment of lacritin (Lacripep), a broad …

Pubmed.ncbi.nlm.nih.gov

TearSolutions, Inc., Announces Results From First-In-Human …

Established Lacripep’s safety and tolerability as well as its ability to significantly improve clinically relevant signs and symptoms of DED. Patients in the study experienced …

Tearsolutions.com

Dry Eye: What’s in the Pipeline? - Review of …

Jun 15, 2021 Lacripep (Tear Solutions ) is a first-in-class topical synthetic peptide treatment for dry eye. It’s a synthetic tear protein fragment of Lacritin, which is a nanomolar concentration constituent of normal …

Reviewofophthalmology.com

New Dry Eye Drug is First That Aims to Treat Cause, …

Jan 4, 2017 Lacripep is a short synthetic fragment of lacritin. If successful, Lacripep would be the first drug to treat that cause of dry eye. “We think that dry-eye disease may be much simpler than people have thought in the …

News.virginia.edu

Lacripep for the Treatment of Primary Sjögren–Associated Ocular …

Jul 28, 2022 In this first-in-human study of Lacripep, a broad regulator of ocular surface homeostasis, safety data, and efficacy signals was established to guide further study. …

Ncbi.nlm.nih.gov

Our Solution - LacripepTM - Tear Solutions

Feb 16, 2021 The co-founder discovered ‘lacritin’, a natural tear protein selectively deficient in dry eye and yet when added topically to eyes of dry eye animals restores …

Tearsolutions.com

A synthetic tear protein resolves dry eye through …

Aug 30, 2022 Lacripep achieves these outcomes through re-establishing functional sensory innervation of the corneal epithelium and can do so despite the presence of chronic ocular inflammation. Thus, we have …

Cell.com

Lacripep (synthetic lacritin) / TearSolutions - LARVOL

Lacripep for the Treatment of Primary Sjögren's-Associated Ocular Surface Disease: Results of the First-In-Human Study. (PubMed, Cornea) - "This first-in-human study of …

Delta.larvol.com

Topical lacritin C-terminal peptide 'Lacripep - ARVO Journals

Conclusions : Lacripep™ appears to be rapidly efficacious for both sign and symptom in primary Sjögren's syndrome, the most severe form of dry eye. This is the largest …

Iovs.arvojournals.org

Lacritin’s active C-terminal peptide, ‘Lacripep’, as an efficient and ...

Conclusions: Lacripep appears to improve corneal epithelial integrity, promote tear secretion, restore sensory innervation and reduce inflammation of the diseased cornea …

Iovs.arvojournals.org

(PDF) Lacripep for the Treatment of Primary Sjögren

A, Mature Lacritin is a 119 amino acid glycoprotein found in human tears. B, Lacripep (a.k.a. "N-94/C-6") is a synthetic 19 amino acid peptide fragment of lacritin (Credit: Jeff Romano).

Researchgate.net

Lacripep for the Treatment of Primary.84 - tearsolutions.com

Lacripep (TearSolutions, Charlottesville, VA) is an investigational synthetic 19 amino acid peptide fragment of lacritin.1,2The 19 amino acid synthetic fragment retains all known …

Tearsolutions.com

Should dry eye sufferers be excited about Lacripep?

Oct 11, 2019 In this way, Lacripep treats the underlying cause of dry eye disease, rather than providing symptomatic relief like many treatments. No other dry-eye drug has this …

Theeyepractice.com.au

Lacripep for the Treatment of Primary Sjögren's-Associated Ocular ...

Purpose: The purpose of this study was to assess the safety, tolerability, dosing, and efficacy of the active 19 amino acid fragment of lacritin (Lacripep), a broad regulator of …

Med.virginia.edu

A synthetic tear protein resolves dry eye through promoting …

Here, using a mouse model of aqueous-deficient dry eye, we reveal that topical application of the synthetic tear protein Lacripep reverses the pathological outcomes of dry eye …

Cell.com

A synthetic tear protein resolves dry eye through promoting …

Aug 8, 2022 Lacripep re-establishes functional corneal nerve-epithelial interactions during dry eye disease progression (A) Schematic of the treatment regimen showing data …

Ncbi.nlm.nih.gov

TearSolutions, Inc. Announces Outcome of Type C Meeting with

Feb 14, 2022 Lacripep was patented by Dr. Gordon Laurie, a professor at the University of Virginia, based on his groundbreaking NIH funded research into the composition of …

Biospace.com

TearSolutions planning Phase II/III trials for therapy to treat dry …

Feb 25, 2022 “The feedback from FDA and our advisors, along with the learnings from our Phase I/II first-in-human trial has us convinced that we are on a path to bringing a novel …

Ophthalmologytimes.com

Lacripep for the Treatment of Primary Sjögren–Associated... : Cornea

In this first-in-human study of Lacripep, a broad regulator of ocular surface homeostasis, safety data, and efficacy signals was established to guide further study. Lacripep has …

Journals.lww.com

A Look at the Dry-Eye Treatment Pipeline - Review of …

Jun 10, 2023 This research established Lacripep’s safety and tolerability as well as its ability to significantly improve clinically relevant signs and symptoms of dry-eye disease, …

Reviewofophthalmology.com

Molecular information of LP-A96, A96, and Lacripep.

Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan …

Researchgate.net

TearSolutions, Inc. Announces Outcome of Type C Meeting

Feb 14, 2022 About Lacripep Lacripep was patented by Dr. Gordon Laurie, a professor at the University of Virginia, based on his groundbreaking NIH funded research into the …

Globenewswire.com

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