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Related websites
Hepatic stellate cell - Wikipedia
Hepatic stellate cells can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the presence of multiple lipid droplets in their cytoplasm. Cytoglobin expression has been shown to be a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. In murine (rats, mice) liver, reelin expressed by Ito cells has been shown to be a reliable marker in discerning the…
En.wikipedia.orgHepatic Stellate Cells in Physiology and Pathology - PMC
Hepatic stellate cells (HSCs) are resident mesenchymal cells located in the perisinusoidal area between endothelial cells and hepatocytes known as the Space of Disse (Figure …
Ncbi.nlm.nih.govHuman hepatic stellate cell isolation and characterization
The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis. …
Pubmed.ncbi.nlm.nih.govInitiation of hepatic stellate cell activation extends into chronic ...
Nov 27, 2021 Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and …
Nature.comMechanisms of hepatic stellate cell activation - Nature
May 10, 2017 Key Points. Activation of hepatic stellate cells (HSCs) into proliferative, fibrogenic myofibroblasts is well established as the central driver of hepatic fibrosis in experimental and human liver ...
Nature.comHepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells ...
Outgrowth of activated stellate cells from human liver biopsy material has gained favor (60, 691) and is reminiscent of earlier studies (182, 672), albeit now utilizing more …
Ncbi.nlm.nih.govFriend or foe? The elusive role of hepatic stellate cells in liver ...
Aug 7, 2023 Hepatic stellate cells (HSCs) drive liver fibrosis and are closely linked to liver cancer development. ... Payen, V. L. et al. Single-cell RNA sequencing of human …
Nature.comHuman hepatic stellate cell lines, LX-1 and LX-2: new …
Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, there is a need …
Gut.bmj.comHepatic stellate cells in physiology and pathology
Mar 20, 2022 Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury. HSCs are primarily known for their …
Physoc.onlinelibrary.wiley.comHuman Hepatic Stellate Cells: Isolation and Characterization
Abstract. Liver fibrosis of different etiologies is characterized by activation of hepatic stellate cells (aHSCs) into collagen type I secreting myofibroblasts, which produce …
Link.springer.comHepatic stellate cells - from past till present: morphology, human ...
Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an extraordinary mesenchymal cell, essential for both hepatocellular function and lesions, …
Pubmed.ncbi.nlm.nih.govHuman hepatic stellate cell lines, LX-1 and LX-2: new tools for ...
Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in …
Pubmed.ncbi.nlm.nih.govHuman hepatic stellate cell isolation and characterization
Nov 1, 2017 The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic …
Link.springer.comHepatic Stellate Cell Regulation of Liver Regeneration and Repair
Nov 13, 2020 The hepatic mesenchyme has been studied extensively in the context of liver fibrosis; however, much less is known regarding the role of mesenchymal cells …
Ncbi.nlm.nih.govGeneration of functionally competent hepatic stellate cells from …
Nov 8, 2022 In this article, Xiang and colleagues develop a new method to generate both endoderm- and mesoderm-derived quiescent hepatic stellate cells (qHSCs). These …
Cell.comOpposing roles of hepatic stellate cell subpopulations in ... - Nature
Oct 5, 2022 Pradere, J. P. et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. …
Nature.comGeneration of Hepatic Stellate Cells from Human Pluripotent Stem …
Jul 5, 2018 The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources for relevant cell types, such …
Pubmed.ncbi.nlm.nih.govHepatic stellate cells in liver development, regeneration, and cancer
May 1, 2013 Activated hepatic stellate cells are present between endothelial cells and cancer cell trabeculae in patients with HCC , and conditioned media from activated …
Ncbi.nlm.nih.govRole of WISP1 in Stellate Cell Migration and Liver Fibrosis - MDPI
The mechanisms underlying the remarkable capacity of the liver to regenerate are still not completely understood. Particularly, the cross-talk between cytokines and cellular …
Mdpi.comEGCG suppressed activation of hepatic stellate cells by ... - Springer
6 days ago However, the functional role and underlying mechanism of EGCG in stimulating of hepatic stellate cells (HSCs) remain unexplored in transcriptomics …
Link.springer.comA human liver cell atlas reveals heterogeneity and epithelial ...
Jul 10, 2019 Single-cell RNA sequencing of cells from healthy human liver, hepatocellular carcinoma and chimaeric mouse liver identifies subtypes of liver cells, epithelial …
Nature.comInhibition of heme-thiolate monooxygenase CYP1B1 prevents …
Sep 25, 2024 Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in liver fibrogenesis. We showed that the expression of the heme-thiolate …
Science.orgSingle-cell RNA sequencing of human liver reveals hepatic stellate …
Mar 21, 2021 Here, single-cell RNA-sequencing was used to unravel the heterogeneity of human liver cells, in particular of hepatocytes (HEPs) and hepatic stellate cells …
Pubmed.ncbi.nlm.nih.govRadiation-sensitive circRNA hsa_circ_0096498 inhibits radiation …
1 day ago Radiation-induced liver fibrosis (RILF) is a common manifestation of radiation-induced liver injury (RILI) and is caused primarily by activated hepatic stellate cells …
Translational-medicine.biomedcentral.comDirected differentiation of human induced pluripotent stem cells …
Apr 16, 2021 The liver is a complex organ containing not only hepatocytes—parenchymal cells that are the main cell type of the organ—but also nonparenchymal cells, including …
Nature.comPurification and Isolation of Hepatic Stellate Cells - PubMed
Quiescent human hepatic stellate cells (HSCs) serve as important reservoirs of fat-soluble vitamins in the body, namely vitamin A. In an activated form, HSCs are the drivers of …
Pubmed.ncbi.nlm.nih.gov