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Proteomics of the corpus callosum to identify novel factors …

RESEARCH Open Access Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice Fan Yang1†, Yudong Guan2†, Xiao Feng1, Arndt Rolfs1, Hartmut Schlüter2* and Jiankai Luo1* Abstract

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Proteomics of the corpus callosum to identify novel factors …

Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the NPC intracellular cholesterol transporter 1 or 2 (Npc1 or Npc2). Npc1 plays key roles in both neurons and oligodendrocytes during myelination, …

Molecularbrain.biomedcentral.com

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